ENDODONTICS
Selected Recent Publications
  • Shivani Ruparel,Dustin Green, Paul Chen, Kenneth M. Hargreaves. The Cytochrome P450 Inhibitor, Ketoconazole, Inhibits OLAM-mediated Peripheral Inflammatory Pain. Mol Pain. 2012 Sep 24;8:73
  • Shivani Ruparel, Michael A. Henry, Armen Akopian, Mayur Patil, Linda Roman, Kenneth M. Hargreaves. Plasticity of Cytochrome P450 Isozyme Expression in Rat Trigeminal Ganglia Neurons During Inflammation. Pain. 2012 Oct;153(10):2031-9
  • Lautner Meeghan,Ruparel Shivani,Patil Mayur, Hargreaves Kenneth. In vitro sarcoma cells release a lipophilic substance that activates the pain transduction system via TRPV1. Ann Surg Oncol. 2011 Mar;18(3):866-71.
    • Abstracts
  • Shivani Ruparel, Dustin Green, Paul Chen and Kenneth Hargreaves. Mechanism by which Oxidized Linoleic Acid Metabolites mediate Inflammation-induced Nociception. 2012 Annual Society for Neuroscience Meeting. Poster Presentation.
  • Shivani Ruparel, Dustin Green, Paul Chen, Linda Roman, Michael Henry, Armen Akopian and Kenneth Hargreaves. Role of Cytochrome P450 Enzymes in Oxidized Linoleic Acid Metabolite-Mediated Inflammatory Pain. 2012 Annual American Pain Society Meeting. Poster Presentation.
  • Shivani Ruparel, Dustin Green, Paul Chen and Kenneth Hargreaves. Cytochrome P450 Enzymes play a role in Oxidized Linoleic Acid Metabolite-Mediated Peripheral Inflammatory Pain. 2012 International Association for the Study of Pain. Poster Presentation (Accepted)
  • Shivani Ruparel, Paul Chen, Armen Akopian Michael Eskander and Kenneth Hargreaves. Role of NGF and OLAMs in the Transition from Acute to Chronic Pain. 2011 Annual Meeting for Society for Neuroscience. Poster Presentation.
  • Shivani Ruparel, Dustin Green, Linda Roman, Michael Henry, and Kenneth Hargreaves. Role of Cytochrome P450 Enzymes in Oxidized Linoleic Acid Metabolite-Mediated Inflammatory Pain. 2011 Behavior, Biology and Chemistry Meeting. Oral Presentation.
  • Shivani Ruparel, Paul Chen, Armen Akopian and Kenneth Hargreaves. Role of NGF and OLAMs in the Transition from Acute to Chronic Pain. 2011 American Pain Society, Austin, Texas. Poster Presentation
  • Shivani Ruparel, Gabriella Helesic, Mayur Patil, Michael Henry and Kenneth Hargreaves . Expression of Cytochrome P450 Isoforms in Rat Nociceptive Neurons. 2010 Meeting of International Association for the study of Pain. Montreal, Canada. Poster Presentation
  • Shivani Ruparel, Dustin Green, Amol Patwardhan, Mayur Patil, Kenneth Hargreaves. Role of Cytochrome P450 enzymes in OLAM-mediated Thermal Nociception. 2010 Annual Meeting for the Society of Neuroscience, San Diego, CA. Poster Presentation
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Research Group Faculty

 
Shivani Ruparel

Shivani Ruparel, MS, PhD

Assistant Professor/Research

Ph.D., University of Texas Health Science Center at San Antonio

Office: 210-567-6668
Email: Ruparels@uthscsa.edu

 

Keywords

Molecular Neurobiology, Pharmacology, Electrphysiology, Polyunsaturated fatty acids, TRPV1, TRPA1, Trk-receptors, Receptor interaction,, Inflammatory mediators, Nocicepton, Pain models, Cancer and Pain.

 

Research Summary

Research Summary Our research involves investigating the signaling events involved in the regulation of peripheral pain pathways. Our study mainly focuses on the regulation and activation of vanilloid channels such as TRPV1 and TRPA1 in several different pain models including inflammatory, burn as well as chronic pain. Currently, I am also studying regulation of these channels in cancer pain. I am particularly interested in studying the regulation of peripheral nociceptors innervating the tumor cells and investigating the role of certain lipids that are released from cancer cells in activating and/or sensitizing the vanilloid channels. Peripheral block of this activation will potentially reverse cancer-induced allodynia with much less adverse effects. Our laboratory uses techniques like RT-PCR, live-imaging, electrophysiology, ELISAs and radioimmunoassays, microarray analysis, immunostaining, rodent behavior etc.

 
 
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